Synergistic activation of the mkp‐1 gene by protein kinase A signaling and USF, but not c‐Myc

FEBS Letters

Burkhardt, H.²  Sommer, Anette²  Lüscher, Bernhard²  Keyse, Steven M.¹ 

[1] ICRF Molecular Pharmacology Unit, Biomedical Research Centre, Ninewells Hospital, Dundee, UK;Institut für Molekularbiologie, Medizinische Hochschule Hannover, Carl-Neuberg Strasse 1, 30625 Hannover, Germany

关键词: Mitogen-activated protein kinase;    Mitogen-activated protein kinase phosphatase 1;    Upstream stimulatory factor;    Myc;    Protein kinase A;    Signaling;   

DOI  :  10.1016/S0014-5793(00)01566-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Mitogen-activated protein kinase phosphatase 1 (MKP-1) is negatively regulating mitogen-activated protein kinases and is therefore involved in early signaling processes. The expression of the mkp-1 gene is induced by growth factors and stress. The promoters of the human and murine mkp-1 genes contain several conserved DNA binding elements, including two cAMP response elements and an E box. We observed that the upstream stimulatory factor (USF), but not c-Myc, activated mkp-1. USF synergized with protein kinase A, thus providing evidence for a role of the E box, during signal-regulated stimulation of mkp-1.

【 授权许可】

Unknown