FEBS Letters | |
Galectin‐3 overexpression protects from cell damage and death by influencing mitochondrial homeostasis | |
Malorni, Walter1  Matarrese, Paola1  Semeraro, Maria Letizia1  Natoli, Clara2  Iacobelli, Stefano2  Tinari, Nicola2  | |
[1] Department of Ultrastuctures, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy;Department of Oncology and Neurosciences, University of Chieti, Chieti, Italy | |
关键词: Galectin-3; Oxidative balance; Cell injury; Cell death; | |
DOI : 10.1016/S0014-5793(00)01547-7 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Galectins are a family of proteins involved in several cell processes, including their survival and death. Galectin-3 has in particular been described as an anti-apoptotic molecule entangled with a number of subcellular activities including anoikis resistance. In this work we partially address the mechanisms underlying this activity pointing at two key factors in injury progression: the alteration of mitochondrial membrane potential and the formation of reactive oxygen species. Overexpression of galectin-3 appears in fact to exert a protective effect towards both these events. On the basis of these data, we propose a reappraisal of the role of galectin-3 as a regulator of mitochondrial homeostasis.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912020309370ZK.pdf | 378KB | download |