Pain peptides. Solution structure of orphanin FQ2

FEBS Letters

Guerrini, Remo¹  Temussi, Piero A²  Amodeo, Pietro³  Tancredi, Teodorico³  Salvadori, Severo¹  López Méndez, Blanca³ 

[1] Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Via Fossato di Mortara 17/19, I-44100 Ferrara, Italy;Dipartimento di Chimica, Università di Napoli Federico II, Via Mezzocannone 4, I-80134 Naples, Italy;Istituto di Chimica MIB, CNR, Via Toiano 6, Arco Felice, I-80072 Naples, Italy

关键词: Nociception;    Bioactive peptide;    Opioid;    Conformation;    Nuclear magnetic resonance;   

DOI  :  10.1016/S0014-5793(00)01513-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Orphanin FQ2 (OFQ2) is a novel heptadecapeptide generated from prepronociceptin (PPNOC), the same precursor of nociceptin/orphanin FQ and nocistatin. OFQ2 is a potent analgesic when administered both supraspinally and spinally. In order to clarify the structural relationship with all peptides generated from PPNOC, we have undertaken the conformational study of OFQ2 in water and in structure-promoting solvent media. Nuclear magnetic resonance data and theoretical calculations are consistent with a well defined helical structure from Met⁵ to Ser¹⁶. The uniform distribution of hydrophobic residues along the helix suggests that OFQ2 may interact with the transmembrane helices of a receptor akin to those of nociceptin and opioids.

【 授权许可】

Unknown