Caloric restriction prevents oxidative damage induced by the carcinogen clofibrate in mouse liver

FEBS Letters

Ong, Choon Nam²  Qu, Bin¹  Lee, Bee Lan²  Halliwell, Barry¹  Li, Qiu-Tian¹ 

[1] Department of Biochemistry, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260, Singapore;Department of Community, Occupational and Family Medicine, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260, Singapore

关键词: Clofibrate;    Cancer;    Peroxisome proliferator;    Protein carbonyl;    8-Hydroxy-2′-deoxyguanosine;   

DOI  :  10.1016/S0014-5793(00)01506-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Long-term caloric restriction in rodents is known to decrease levels of oxidative damage, which may contribute to an ‘anti-ageing’ effect. We show here that a shorter period (10 months) of caloric restriction had only small effects on levels of oxidative DNA and protein damage in the livers of mice, but completely attenuated increased oxidative damage caused by the carcinogen clofibrate. Since clofibrate is thought to exert its actions by increasing oxidative damage, our data suggest that 10 months of caloric restriction can increase the resistance of tissues to agents inducing oxidative stress. This may be an important factor in explaining how caloric restriction decreases cancer incidence.

【 授权许可】

Unknown