Mutually exclusive expression of βIII‐tubulin and vimentin in adrenal cortex carcinoma SW13 cells

FEBS Letters

Gallo, Jean-Marc¹  Butler, Rachel¹  Robertson, Janice¹ 

[1] Department of Neurology, Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK

关键词: βIII-Tubulin;    Vimentin;    Adrenal cortex;    Carcinoma;    Cytoskeleton;    Neurogenesis;   

DOI  :  10.1016/S0014-5793(00)01316-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

During embryogenesis, the maturation of neuroblasts into neurones is accompanied by the down-regulation of vimentin and by the expression of neuronal microtubular proteins. Here, we show that human adrenal cortex SW13 cells express β_III-tubulin, MAP2b and tau. Analysis of vimentin-positive and -negative subclones of SW13 cells revealed that, under defined cultured conditions, β_III-tubulin and MAP2b were present only in vimentin-deficient cells and that β_III-tubulin repression occurred at the transcriptional level in vimentin-positive cells. These results suggest that vimentin repression and β_III-tubulin expression are co-ordinated by an upstream mechanism relevant to the control of cytoskeletal protein expression during neuronal development.

【 授权许可】

Unknown