期刊论文详细信息
FEBS Letters
A novel C‐terminal kinesin subfamily may be involved in chromosomal movement in Caenorhabditis elegans 1
Siddiqui, Shahid S.1  Siddiqui, Z.K.2  Malik, A.B.2  Ali, M.Yusuf1 
[1] Laboratory of Molecular Biology, Department of Ecological Engineering, Toyohashi University of Technology, Tempaku-cho, Toyohashi 441-8580, Japan;Department of Pharmacology, University of Illinois, 4370 Molecular Biology Research Building, M/C 867, 900 South Ashland Avenue, Chicago, IL 60607, USA
关键词: Kinesin-like protein;    Embryonic development;    C-terminal motor;    Cell division;    Chromosomal movement;    Caenorhabditis elegans;   
DOI  :  10.1016/S0014-5793(00)01258-8
学科分类:生物化学/生物物理
来源: John Wiley & Sons Ltd.
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【 摘 要 】

C-terminal kinesin motor proteins, such as the Drosophila NCD and yeast KAR3, are involved in chromosomal segregation. Previously we have described two orthologs of NCD in Caenorhabditis elegans, KLP-3 and KLP-17, which also participate in chromosome movement. Here we report cDNA cloning of klp-15 and klp-16, and the expression pattern of the genes encoding C-terminal motor kinesins including klp-15 and klp-16. Interestingly KLP-15 and KLP-16 form a unique class of C-terminal kinesins, distinct from the previously known C-terminal motors in other organisms. Using in situ hybridization and RNA interference assay, we show that although all of these motors mediate chromosome segregation, they do so in a combination of unique and overlapping manners, suggesting a complex hierarchy of kinesin motor function in metazoans.

【 授权许可】

Unknown   

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