Progress in understanding structure–function relationships in respiratory chain complex II

FEBS Letters

Ackrell, Brian A.C¹ 

[1] Molecular Biology Division, D.V.A. Medical Center and Department of Biochemistry and Biophysics, University of California, 4150 Clement Street, San Francisco, CA 94121, USA

关键词: Complex II;    Fumarate reductase;    Covalent flavin;    Iron–sulfur center;    Cytochrome b;    Quinone reductase;   

DOI  :  10.1016/S0014-5793(99)01749-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Complex II (succinate:quinone oxidoreductase) of aerobic respiratory chains oxidizes succinate to fumarate and passes the electrons directly into the quinone pool. It serves as the only direct link between activity in the citric acid cycle and electron transport in the membrane. Finer details of these reactions and interactions are but poorly understood. However, complex II has extremely similar structural and catalytic properties to quinol:fumarate oxidoreductases of anaerobic organisms, for which X-ray structures have recently become available. These offer new insights into structure–function relationships of this class of flavoenzymes, including evidence favoring protein movement during catalysis.

【 授权许可】

Unknown