Aberrant overexpression of 53BP2 mRNA in lung cancer cell lines

FEBS Letters

Mori, Toshiyuki²  Okamoto, Hiroshi²  Okamoto, Takashi²  Takahashi, Naoko²  Ueda, Ryuzo¹ 

[1] Second Department of Internal Medicine, Nagoya City University Medical School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, Japan;Department of Molecular Genetics, Nagoya City University Medical School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, Japan

关键词: p53-binding protein 2;    p53;    DNA-damaging agent;    53BP2;    p53-binding protein 2;    SH3;    Src-homology 3;    UV;    ultraviolet;    CDDP;    cis-diamine-dichloroplatinum;    RT-PCR;    reverse transcriptase-PCR;   

DOI  :  10.1016/S0014-5793(99)01726-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The p53-binding protein 2 (53BP2) was identified as a binding protein to a tumor suppressor p53. We examined the genetic aberrations of 53BP2 gene in various human cancer cell lines. Although no gross genomic alteration or mutation of 53BP2 gene was observed, 53BP2 mRNA levels were highly variable. There was no association between the 53BP2 mRNA level and the p53 status. When we examined sensitivities of these cell lines to DNA-damaging agents including UV irradiation, X-ray irradiation and cis-diamine-dichloroplatinum (CDDP), we found that higher 53BP2 mRNA expression was correlated with the sensitivity to these agents.

【 授权许可】

Unknown