Glucose regulates pancreatic preprosomatostatin I expression

FEBS Letters

Ehrman, Melissa M¹  Melroe, Gregory T¹  Sheridan, Mark A¹  Kittilson, Jeffrey D¹ 

[1] Department of Zoology and Regulatory Biosciences Center, North Dakota State University, Fargo, ND 58105, USA

关键词: Somatostatin;    mRNA slot-blot quantitation technique;    Rainbow trout model system;    HEPES;    4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid;    PPSS;    preprosomatostatin;    SS;    somatostatin;   

DOI  :  10.1016/S0014-5793(99)01723-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Rainbow trout were used as a model system to evaluate the role of glucose in regulating the expression of preprosomatostatin I. Glucose increased pancreatic levels of preprosomatostatin I mRNA in vivo, in concert with elevated plasma somatostatin levels, and in vitro. Glucose-stimulated expression of preprosomatostatin I mRNA required the uptake, phosphorylation, and subsequent metabolism of the sugar in pancreatic islets. These results suggest that glucose modulates both the production and release of somatostatin.

【 授权许可】

Unknown