A kinetic study of the oxidation effects of amphotericin B on human low‐density lipoproteins

FEBS Letters

Barwicz, Joanna¹  Tancrède, Pierre¹  Gruda, Ilona¹ 

[1] Département de Chimie-Biologie, Université du Québec à Trois-Rivières, P.O. Box 500, Trois-Rivières, Que. G9A 5H7,Canada

关键词: Oxidation;    Low-density lipoprotein;    Amphotericin B;    Fungizone;    AmBisome;   

DOI  :  10.1016/S0014-5793(99)01731-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The UV-visible results of this kinetic study show that amphothericin B as Fungizone is a much stronger oxidant than CuSO₄, itself a powerful oxidant of low-density lipoprotein (LDL). Amphotericin B as AmBisome alone has no oxidizing effect on LDL while a mixture of both AmBisome and CuSO₄ induces an important potentialization of the LDL oxidation. These results allow us to believe that the high toxicity of amphotericin B is related to its capacity to modify and to weaken the structure of LDL. In addition, differential scanning calorimetry experiments show that the oxidative modifications of LDL by CuSO₄ or by amphotericin B proceed through different mechanisms.

【 授权许可】

Unknown