Progress toward an explicit mechanistic model for the light‐driven pump, bacteriorhodopsin

FEBS Letters

Lanyi, Janos K¹ 

[1] Department of Physiology & Biophysics, University of California, Irvine, CA 92697, USA

关键词: Bacteriorhodopsin;    Membrane protein;    Proton transport;    Bioenergetics;   

DOI  :  10.1016/S0014-5793(99)01685-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Recent crystallographic information about the structure of bacteriorhodopsin and some of its photointermediates, together with a large amount of spectroscopic and mutational data, suggest a mechanistic model for how this protein couples light energy to the translocation of protons across the membrane. Now nearing completion, this detailed molecular model will describe the nature of the steric and electrostatic conflicts at the photoisomerized retinal, as well as the means by which it induces proton transfers in the two half-channels leading to the two membrane surfaces, thereby causing unidirectional, uphill transport.

【 授权许可】

Unknown