FEBS Letters | |
Expression of factor X in both the rat brain and cells of the central nervous system | |
Morita, Takashi1  Shikamoto, Yasuo1  | |
[1] Department of Biochemistry, Meiji Pharmaceutical University, Noshio, Kiyose, Tokyo 204-8588, Japan | |
关键词: Factor X; Brain; Central nervous system; Thrombin; Prothrombin; | |
DOI : 10.1016/S0014-5793(99)01657-9 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Prothrombin is expressed in the central and peripheral nervous systems. However, the mechanism responsible for the activation of prothrombin to thrombin by the activated form of factor X in the central and peripheral nervous systems remains to be explored. Here, we investigated the expression of factor X mRNA in the brain and some cell lines derived from the central nervous system. Reverse transcription-polymerase chain reaction (RT-PCR) demonstrated the expression of mRNA encoding factor X in the rat brain, A172 (human glioblastoma) and GOTO (human neuroblastoma) cells. The sequences of PCR-derived fragments were identical to those reported for rat and human factor X. These results indicated the synthesis of factor X in the cells of the central nervous system.
【 授权许可】
Unknown
【 预 览 】
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RO201912020308783ZK.pdf | 120KB | download |