期刊论文详细信息
FEBS Letters
Expression of factor X in both the rat brain and cells of the central nervous system
Morita, Takashi1  Shikamoto, Yasuo1 
[1] Department of Biochemistry, Meiji Pharmaceutical University, Noshio, Kiyose, Tokyo 204-8588, Japan
关键词: Factor X;    Brain;    Central nervous system;    Thrombin;    Prothrombin;   
DOI  :  10.1016/S0014-5793(99)01657-9
学科分类:生物化学/生物物理
来源: John Wiley & Sons Ltd.
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【 摘 要 】

Prothrombin is expressed in the central and peripheral nervous systems. However, the mechanism responsible for the activation of prothrombin to thrombin by the activated form of factor X in the central and peripheral nervous systems remains to be explored. Here, we investigated the expression of factor X mRNA in the brain and some cell lines derived from the central nervous system. Reverse transcription-polymerase chain reaction (RT-PCR) demonstrated the expression of mRNA encoding factor X in the rat brain, A172 (human glioblastoma) and GOTO (human neuroblastoma) cells. The sequences of PCR-derived fragments were identical to those reported for rat and human factor X. These results indicated the synthesis of factor X in the cells of the central nervous system.

【 授权许可】

Unknown   

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