AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis

FEBS Letters

Lödige, Inga¹  Page, Grit¹  Kögel, Donat¹  Scheidtmann, Karl Heinz¹ 

[1] Institute of Genetics, University of Bonn, Roemerstr. 164, D-53117 Bonn, Germany

关键词: Dlk/ZIP kinase;    Two-hybrid screen;    Transcription factor;    Acidic domain;    Apoptosis;    Par-4;   

DOI  :  10.1016/S0014-5793(99)01529-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Dlk, also known as ZIP kinase, is a serine/threonine kinase that is tightly associated with nuclear structures. Under certain conditions, which require cytoplasmic localization, Dlk can induce apoptosis. In search for interaction partners that might serve as regulators or targets of this kinase we identified apoptosis antagonizing transcription factor (AATF), a nuclear phosphoprotein of 523 amino acids. The 1.8 kb mRNA seems to be ubiquitously expressed. AATF contains an extremely acidic domain and a putative leucine zipper characteristic of transcription factors. Indeed, a Gal4-BD-AATF fusion protein exhibited strong transactivation activity. Interestingly, AATF interfered with Dlk-induced apoptosis.

【 授权许可】

Unknown