MyoD binds to Mos and inhibits the Mos/MAP kinase pathway

FEBS Letters

Pelpel, Karine¹  Leibovitch, Serge A.¹  Lenormand, Jean Luc¹  Solhonne, Brigitte¹  Leibovitch, Marie Pierre¹ 

[1] Laboratoire de Génétique Oncologique UMR 1599 CNRS, Institut Gustave Roussy, 39, rue Camille Desmoulins, 94800 Villejuif, France

关键词: Mos transformation;    MAP kinase pathway;    MyoD;    Muscle differentiation;   

DOI  :  10.1016/S0014-5793(99)01430-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

When ectopically expressed, the serine/threonine kinase Mos can induce oncogenic transformation of somatic cells by direct phosphorylation of MAP kinase/ERK kinase (MEK1), activating the mitogen-activated protein kinases ERK1 and ERK2. On the other hand, overexpression of Mos in C2C12 myoblasts is not transforming. Mos activates myogenic differentiation by promoting heterodimerization of the MyoD/E12 proteins, increasing the expression of myogenic markers and the positive autoregulatory loop of MyoD. In this study, we show that in myogenic cells, the mitogenic and oncogenic signalling from the Mos/MEK/ERK pathway is suppressed by MyoD through the formation of a heterotrimeric complex.

【 授权许可】

Unknown