Tetraspanins expressed in the embryonic chick nervous system

FEBS Letters

Bixby, John L.²  Perron, Jeanette C.¹ 

[1] Department of Molecular and Cellular Pharmacology, R-189, University of Miami School of Medicine, 1600 NW 10 Ave., Miami, FL 33136, USA;Neuroscience Program, University of Miami School of Medicine, 1600 NW 10 Ave., Miami, FL 33136, USA

关键词: Tetraspanin;    Development;    Spinal cord;    Brain;    Avian;    Sensory neuron;   

DOI  :  10.1016/S0014-5793(99)01429-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Proteins of the tetraspanin superfamily participate in the formation of plasma membrane signaling complexes; recent evidence implicates neuronal tetraspanins in axon growth and target recognition. We used a degenerate PCR screen to identify cDNAs encoding tetraspanins expressed in the embryonic spinal cord. Two cDNAs identified apparently represent chick homologues of NAG-2 (cnag) and CD9 (chCD9). A third clone encodes a novel tetraspanin (neurospanin). All three mRNAs are widely expressed but exhibit developmentally distinct patterns of expression in the nervous system. Both neurospanin and cnag exhibit high relative expression in nervous tissue, including brain, spinal cord and dorsal root ganglia (DRG).

【 授权许可】

Unknown