Human apolipoprotein A‐IV reduces gastric acid secretion and diminishes ulcer formation in transgenic mice

FEBS Letters

Baroukh, Nadine³  Zakin, Mario M³  Vergnes, Laurent³  Ochoa, Alberto³  Baralle, Francisco E²  Moizo, Laurent¹  Bado, André¹  Léhy, Thérèse¹  Baralle, Marco² 

[1] Unité de Recherche de Gastro-entérologie, INSERM 10, Hôpital Bichat. 170, boulevard Ney, 75877 Paris, Cedex 18, France;ICGEB. Padriciano 99, 34012 Trieste, Italy;Unité d'Expression des Gènes Eucaryotes, Institut Pasteur, 28, rue du Dr. Roux, 75724 Paris, Cedex 15, France

关键词: Transgenic mouse;    Gastric mucosa;    Apolipoprotein A-IV;    Indomethacin;    Ulcer;    Gastric acid secretion;    apoA-IV;    apolipoprotein A-IV;    RIA;    radioimmunoassay;    NS;    not significant;    ECL cell;    enterochromaffin-like cell;   

DOI  :  10.1016/S0014-5793(99)01332-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have investigated the involvement of human apolipoprotein A-IV (apoA-IV) in gastric acid secretion and ulcer formation in recently generated apoA-IV transgenic mice. Compared to control littermates, transgenic animals showed a gastric acid secretion decreased by 43–77% whereas only slight variations were observed in the different cell population densities within the gastric mucosa. In addition, no variation in gastrin levels was observed. Transgenics were protected against indomethacin-induced ulcer formation, with lesions diminishing by 45 to 64% compared to controls. These results indicate that endogenous apoA-IV expression can regulate gastric acid secretion and ulcer development.

【 授权许可】

Unknown