Enhanced anti‐HIV‐1 activity of CC‐chemokine LD78β, a non‐allelic variant of MIP‐1α/LD78α

FEBS Letters

Xin, Xiaomi¹  Shioda, Tatsuo²  Liu, Huanliang²  Nagai, Yoshiyuki¹  Kato, Atsushi¹  Sakai, Yuko¹ 

[1] Department of Viral Infection, Institute of Medical Science, University of Tokyo, Tokyo, Japan;Department of Infectious Diseases, Institute of Medical Science, University of Tokyo, 4-6-1 Shiroganedai, Minato-ku, Tokyo, Japan

关键词: Human immunodeficiency virus type 1;    Chemokine;    Macrophage inflammatory peptide 1α;    LD78β;    CD26/dipeptidyl peptidase IV;   

DOI  :  10.1016/S0014-5793(99)01035-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We compared the anti-HIV-1 activity of CC-chemokine LD78β with that of MIP-1α, another CC-chemokine which shows 94% sequence homology with LD78β. Despite its close similarity to MIP-1α, the anti-HIV-1 activity of LD78β appeared to be nearly 10 times higher than that of MIP-1α. Mutagenesis of MIP-1α showed that the N-terminal additional tetrapeptide, which was present in LD78β and absent in MIP-1α, is responsible for enhanced anti-HIV-1 activity. The N-terminal structure-function relationship of LD78β described here will be of value in understanding the chemokine-receptor interactions and designing anti-HIV-1 compounds based on LD78β.

【 授权许可】

Unknown