Oligonucleotide‐peptide conjugates as potential antisense agents

FEBS Letters

Tashlitsky, Vadim N¹  Romanova, Elena A¹  Oretskaya, Tatiana S¹  Shabarova, Zoe A¹  Korshunova, Galina A¹  Volkov, Eugeny M¹  Zubin, Eugeny M¹ 

[1] Chemical Department and A.N. Belozersky Institute of Physical Chemical Biology, M.V. Lomonosov Moscow State University, Moscow 119899, Russia

关键词: Antisense;    Nucleic acid analogue;    Oligonucleotide-peptide conjugate;    2′-Amino-2′-deoxynucleoside;   

DOI  :  10.1016/S0014-5793(99)00921-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Oligonucleotide-peptide conjugates have several applications, including their potential use as improved antisense agents for interfering with the RNA function within cells. In order to provide robust and generally applicable conjugation chemistry, we developed a novel approach of fragment coupling of pre-synthesized peptides to the 2′-position of a selected nucleotide within an otherwise protected oligonucleotide chain attached to a solid support.

【 授权许可】

Unknown