Micellar catalysis for oxidation of nitric oxide (NO) in the multi‐phase systems in vivo

FEBS Letters

Beda, Nataliya V.¹  Suntsova, Tatiana P.¹ 

[1] Institute of Molecular Genetics, RAS, Kurchatov Sq., Moscow 123182, Russia

关键词: Nitric oxide;    Nitrite;    Partition coefficient;    Competing pathway;    NO catastrophe;    Nitrosation;   

DOI  :  10.1016/S0014-5793(99)00578-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The equation of the dependence of the third-order reaction acceleration due to concentrating the reagents in a small volume of the hydrophobic phase on the partition coefficients of reagents (Q) and on the lipophilic phase fraction (x), [k _app/k ₂=H(Q _NO,Q _O2 ,x)] was analyzed. It was demonstrated that the numeric value of dH/dx at x→0 could not be used in order to calculate the efficiency of catalysis from the experimental data. It was shown that, unlike in two-phase systems (with an aqueous and a hydrophobic phase), the dependence of H on Q in multi-phase systems, that include all in vivo systems, is different. The multiple phase state of the systems has a determining role for a regulation of NO-dependent processes and in the realization of conditions of ‘NO catastrophes’.

【 授权许可】

Unknown