Surfactant protein A and D expression in the porcine Eustachian tube1

FEBS Letters

Paananen, Reija¹  Glumoff, Virpi¹  Hallman, Mikko¹ 

[1] Biocenter Oulu and Department of Pediatrics, University of Oulu, Kajaanintie 52A, PL 5000, 90220 Oulu, Finland

关键词: Surfactant protein A;    Surfactant protein D;    Eustachian tube;    Collectin;    Gene expression;    SP;    surfactant protein;    ET;    Eustachian tube;    CRD;    carbohydrate recognition domain;   

DOI  :  10.1016/S0014-5793(99)00602-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Surfactant proteins A and D are collectins which are considered to play an important role in the innate immunity of lungs. Our aim was to investigate whether surfactant protein A or D is expressed in the porcine Eustachian tube originating from the upper airways. Both surfactant proteins A and D were present in the epithelial cells of the Eustachian tube, as shown by strong immunostaining. Using RT-PCR and Northern hybridization, these collectins were detected in the Eustachian tube. The present study is the first report demonstrating surfactant protein gene expression in the Eustachian tube. Surfactant proteins A and D may be important in the antibody-independent protection of the middle ear.

【 授权许可】

Unknown