Cytoskeleton cross‐talk during cell motility

FEBS Letters

Krylyshkina, Olga¹  Kaverina, Irina¹  Rottner, Klemens¹  Small, J.Victor¹ 

[1] Department of Cell Biology, Institute of Molecular Biology, Austrian Academy of Sciences, Billrothstrasse 11, A-5020 Salzburg, Austria

关键词: Actin;    Microtubule;    Signalling;    Rho;   

DOI  :  10.1016/S0014-5793(99)00530-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Cell crawling entails the co-ordinated creation and turnover of substrate contact sites that interface with the actin cytoskeleton. The initiation and maturation of contact sites involves signalling via the Rho family of small G proteins, whereas their turnover is under the additional influence of the microtubule cytoskeleton. By exerting relaxing effects on substrate contact assemblies in a site- and dose-specific manner, microtubules can promote both protrusion at the front and retraction at the rear, and thereby control cell polarity.

【 授权许可】

Unknown