Transfer RNA modification: influence on translational frameshifting and metabolism

FEBS Letters

Durand, Jérôme M.B¹  Lundgren, Hans K¹  Qian, Qiang¹  Urbonavičius, Jaunius¹  Chen, Peng¹  Björk, Glenn R¹  Hagervall, Tord G¹  Leipuvien≐, Ramun≐¹  Nilsson, Kristina¹ 

[1] Department of Microbiology, Umeå University, S-90187 Umeå, Sweden

关键词: tRNA;    Modified nucleoside;    Frameshifting;    Central metabolism;    Virulence;   

DOI  :  10.1016/S0014-5793(99)00528-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Transfer RNA modification improves the rate of aa-tRNA selection at the A-site and the fitness in the P-site and thereby prevents frameshifting according to a new model how frameshifting occurs [Qian et al. (1998) Mol. Cell 1, 471–482]. Evidence that the presence of various modified nucleosides in tRNA also influences central metabolism, thiamine metabolism, and bacterial virulence is reviewed.

【 授权许可】

Unknown