Modular PH and C2 domains in membrane attachment and other functions

FEBS Letters

Katan, Matilda¹  Allen, Victoria L¹ 

[1] CRC Centre for Cell and Molecular Biology, Chester Beatty Laboratories, Fulham Road, London SW3 6JB, UK

关键词: PH;    pleckstrin homology domain;    PTB;    phosphotyrosine binding domain;    DH;    Dbl homology domain;    CBR;    calcium binding region;    GFP;    green fluorescent protein;    PAF;    platelet activating factor;    Ins(1;    4;    5)P3;    inositol (1;    4;    5)-trisphosphate;    Ins(1;    3;    4;    5)P4;    inositol (1;    3;    4;    5)-tetrakisphosphate;    PtdIns(4;    5)P2;    phosphatidylinositol (4;    5)-bisphosphate;    PtdIns(3;    4;    5)P3;    phosphatidylinositol (3;    4;    5)-trisphosphate;    PKC;    protein kinase C;    PLC;    phospholipase C;    GAP;    GTPase activating protein;    β-ARK;    β-adrenergic receptor kinase;    Btk;    Bruton's tyrosine kinase;    PKB/Akt;    protein kinase B;    product of the Akt gene;    PI-3 kinase;    phosphoinositide 3 kinase;    ARNO;    ARF nucleotide binding site opener;    Sos;    son of sevenless;    SynI C2A/B;    synaptotagmin I first (C2A) and second (C2B) C2 domains;    cPLA2;    cytoplasmic phospholipase A2;    PDK1/2;    3-phosphoinositide-dependent protein kinase 1 and 2;   

DOI  :  10.1016/S0014-5793(99)00531-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The pleckstrin homology and C2 domains are modular protein structures involved in mediating intermolecular interactions. Although they represent distinct domains, there are several parallels regarding their function and type of interactions in which they participate. Both domains are stable structural entities that incorporate variable regions which, in different proteins, can be adapted to perform a specific function through binding to membrane phospholipids or specific protein ligands. A number of recent examples illustrate the function of some of these domains in regulated membrane attachment, with an important role in many cellular signalling pathways.

【 授权许可】

Unknown