Obligate intracellular parasites: Rickettsia prowazekii and Chlamydia trachomatis

FEBS Letters

Andersson, Siv G.E¹  Zomorodipour, Alireza¹ 

[1] Department of Molecular Evolution, Box 590, Biomedical Center, 751 24 Uppsala, Sweden

关键词: Genome evolution;    Intracellular parasite;    Metabolism;    Rickettsia;    Chlamydia;   

DOI  :  10.1016/S0014-5793(99)00563-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Transitions to obligate intracellular parasitism have occurred at numerous times in the evolutionary past. The genome sequences of two obligate intracellular parasites, Rickettsia prowazekii and Chlamydia trachomatis, were published last year. A comparative analysis of these two genomes has revealed examples of reductive convergent evolution, such as a massive loss of genes involved in biosynthetic functions. In addition, both genomes were found to encode transport systems for ATP and ADP, not otherwise found in bacteria. Here, we discuss adaptations to intracellular habitats by comparing the information obtained from the recently published genome sequences of R. prowazekii and C. trachomatis.

【 授权许可】

Unknown