Effects of frontotemporal dementia FTDP‐17 mutations on heparin‐induced assembly of tau filaments

FEBS Letters

Crowther, R.Anthony¹  Goedert, Michel¹  Jakes, Ross¹ 

[1] Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK

关键词: Tau protein mutation;    Tau filament assembly;    Frontotemporal dementia;   

DOI  :  10.1016/S0014-5793(99)00508-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Missense mutations and intronic mutations in the gene for microtubule-associated protein tau cause frontotemporal dementia and Parkinsonism linked to chromosome 17 (FTDP-17). Most missense mutations have as likely primary effect a reduced ability of tau to interact with microtubules. We report here an additional effect of several missense mutations, namely the stimulation of heparin-induced filament assembly of recombinant tau, despite the absence of any change in structure indicated by circular dichroism. These findings indicate that missense mutations in tau lead to frontotemporal dementia through potentially multiple mechanisms.

【 授权许可】

Unknown