Endometrial expression of cellular protooncogene c‐ski and its regulation by estradiol‐17β

FEBS Letters

Soeta, Chie¹  Yamanouchi, Keitaro¹  Harada, Rie¹  Naito, Kunihiko¹  Tojo, Hideaki¹ 

[1]Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan

关键词: C-ski;    Protooncogene;    Uterine epithelial cell;    Proliferation;    Estradiol;   

DOI  :  10.1016/S0014-5793(99)00424-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The expression of the cellular protooncogene c-ski was examined in the rat uterus. In situ hybridization revealed that c-ski mRNA was expressed in the uterus of the adult rat on the day of estrous and localized mainly in the luminal and glandular epithelia. To test the possibility that the expression of c-ski mRNA is induced by estrogen, rats were ovariectomized and estradiol-17β (E₂) was injected. The expression of c-ski mRNA was upregulated 3 h after E₂ treatment, reaching the highest level at 6 h and this persisted until 24 h; the E₂-induced expression of c-ski mRNA was restricted to the luminal and glandular epithelia. These results suggest that the c-ski gene plays a role in uterine epithelial cell proliferation and mediates the proliferative action of E₂.

【 授权许可】

Unknown