Expression of plasminogen‐related gene B varies among normal tissues and increases in cancer tissues

FEBS Letters

Tateno, Tadashi¹  Ichinose, Akitada¹ 

[1] Department of Molecular Pathological Biochemistry, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan

关键词: Gene regulation;    Plasminogen;    Plasminogen-related gene B;    Reverse transcription-polymerase chain reaction;    Tissue-specific expression;    PAP;    preactivation peptide;    PLG;    plasminogen;    PRG;    plasminogen-related gene;    RT;    reverse transcription;   

DOI  :  10.1016/S0014-5793(99)00093-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We previously found that the promoter activity of plasminogen (PLG)-related gene B (PRGB) was 5-fold that of PLG. We have since examined the transcript levels of PRGB among various normal human tissues, and compared these findings with those of PLG. Reverse transcription-PCR analysis revealed that the PRGB expression varied widely among different tissues, while PLG was expressed only in the liver and kidney. RNA samples obtained from cultured cell lines also demonstrated differing PRGB expression. Furthermore, increased PRGB expression was observed in several fresh samples of cancer tissue obtained from cancer patients when compared with surrounding normal tissues.

【 授权许可】

Unknown