The latrophilin family: multiply spliced G protein‐coupled receptors with differential tissue distribution

FEBS Letters

Matsushita, Hiroaki¹  Lelianova, Vera G.¹  Ushkaryov, Yuri A.¹ 

[1] Department of Biochemistry, Imperial College, London SW7 2AY, UK

关键词: α-Latrotoxin;    Latrophilin;    Homolog;    Splicing;    Tissue distribution;   

DOI  :  10.1016/S0014-5793(99)00005-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Latrophilin is a brain-specific Ca²⁺-independent receptor of α-latrotoxin, a potent presynaptic neurotoxin. We now report the finding of two novel latrophilin homologues. All three latrophilins are unusual G protein-coupled receptors. They exhibit strong similarities within their lectin, olfactomedin and transmembrane domains but possess variable C-termini. Latrophilins have up to seven sites of alternative splicing; some splice variants contain an altered third cytoplasmic loop or a truncated cytoplasmic tail. Only latrophilin-1 binds α-latrotoxin; it is abundant in brain and is present in endocrine cells. Latrophilin-3 is also brain-specific, whereas latrophilin-2 is ubiquitous. Together, latrophilins form a novel family of heterogeneous G protein-coupled receptors with distinct tissue distribution and functions.

【 授权许可】

Unknown