Determinants of plasma coenzyme Q10 in humans

FEBS Letters

Ristonmaa, Ulla¹  Tuomainen, Tomi-Pekka¹  Kaikkonen, Jari¹  Nyyssönen, Kristiina¹  Salonen, Jukka T¹ 

[1] Research Institute of Public Health, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland

关键词: Coenzyme Q10;    Confounding factor;    Determinant;    Population study;   

DOI  :  10.1016/S0014-5793(98)01712-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In the present study, we assessed the strongest determinants of plasma coenzyme Q₁₀ (Q₁₀) in 518 men and women (aged 45–70 years) with a stepwise multivariate regression model. Male gender (P<0.001), serum cholesterol (P<0.001), serum γ-glutamyltransferase (P<0.001), serum triglycerides (P<0.001), age (P=0.017) and 4-day alcohol consumption (P=0.03) were the most important factors which were directly associated with plasma Q₁₀. The intensity of conditioning exercise (P=0.03) and use of statins (P<0.05) showed an inverse association with plasma Q₁₀. None of the assessed nutrients increased plasma Q₁₀ levels significantly. Our results suggest that many confounding factors, in addition to serum cholesterol and triglycerides, should be taken into account when the role of plasma Q₁₀ is examined in epidemiological research.

【 授权许可】

Unknown