The lipopolysaccharide‐binding protein participating in hemocyte nodule formation in the silkworm Bombyx mori is a novel member of the C‐type lectin superfamily with two different tandem carbohydrate‐recognition domains 1

FEBS Letters

Imamura, Morikazu²  Koizumi, Nobuo²  Sato, Ryoichi¹  Yaoi, Katsuro²  Iwahana, Hidenori²  Kadotani, Tomoyuki² 

[1] Laboratory of Molecular Mechanism of Bio-Interaction, Graduate School of Bio-Applications and Systems Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei, Tokyo 184-8588, Japan;Department of Applied Biological Science, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan

关键词: Lipopolysaccharide-binding protein;    C-type lectin;    Carbohydrate-recognition domain;    Pattern recognition;    Insect;    Immunity;    LPS;    lipopolysaccharide;    CRD;    carbohydrate-recognition domain;    RACE;    rapid amplification of cDNA ends;    LBP;    LPS-binding protein;   

DOI  :  10.1016/S0014-5793(98)01701-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We recently isolated and characterized the lipopolysaccharide (LPS)-binding protein, BmLBP, from the larval hemolymph of the silkworm Bombyx mori. BmLBP is a pattern recognition molecule that recognizes the lipid A portion of LPS and participates in a cellular defense reaction. This paper describes the cDNA cloning of BmLBP. The deduced amino acid sequence of BmLBP revealed that BmLBP is a novel member of the C-type lectin superfamily with a unique structural feature that consists of two different carbohydrate-recognition domains in tandem, a short and a long form.

【 授权许可】

Unknown