Identification of the mammalian homologues of the Drosophila timeless gene, Timeless1 1

FEBS Letters

Hirose, Matsumi¹  Numano, Rika¹  Hida, Akiko¹  Koike, Nobuya¹  Tei, Hajime¹  Sakaki, Yoshiuki¹ 

[1] Human Genome Center, Institute of Medical Science, University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan

关键词: Circadian rhythm;    Timeless homologue;    Mammalian clock gene;   

DOI  :  10.1016/S0014-5793(98)01597-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have identified novel mammalian homologues of a Drosophila clock gene, timeless, and designated them as human TIMELESS1 (hTIM1) and mouse Timeless1 (mTim1), respectively. These genes were mapped by FISH to chromosomal regions 12q12-13 in human and 10D3 in mouse. The deduced amino acid sequences of hTim1 and mTim1 proteins were 1208 and 1197 amino acids in length and shared 83% identity. Northern blot analysis identified a single transcript of 4.5 kb expressed widely in many tissues examined. Unlike the Drosophila counterpart, the levels of the mTim1 transcript exhibited no prominent circadian oscillation in the mouse brain.

【 授权许可】

Unknown