Lipoprotein (a) stimulates mitogen activated protein kinase in human mesangial cells

FEBS Letters

Piiper, Albrecht²  Bender, Michael¹  Mondorf, Ulrich F.³  Geiger, Helmut³  Herrero, Martina³  Scheuermann, Ernst H.³ 

[1] Department of Biochemistry, Johann Wolfgang Goethe University, Frankfurt am Main, Germany;Division of Gastroenterology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany;Medical Clinic IV, Division of Nephrology, Johann Wolfgang Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany

关键词: Lipoprotein (a);    Mesangial cell;    Mitogen activated protein kinase;    Signal transduction;    Protein kinase C;    Protein kinase A;   

DOI  :  10.1016/S0014-5793(98)01554-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Evidence suggests an important role of elevated serum lipoproteins in the progression of renal glomerulosclerosis. We report here that lipoprotein (a) (Lp(a)) increased phosphorylation and activity of mitogen activated protein kinase (MAPK) in human mesangial cells. When protein kinase C (PKC) was depleted by long-term incubation with the phorbol 12-O-myristate 13-acetate the effect of Lp(a) on MAPK activation was completely inhibited. Forskolin, a stimulator of the adenylyl cyclase, and dibutyryl-cAMP reduced the effect of Lp(a) on MAPK phosphorylation and activation. We conclude that Lp(a) stimulates the MAPK cascade via activation of PKC and that activation of protein kinase A counteracts Lp(a) induced MAPK activation in human mesangial cells.

【 授权许可】

Unknown