Velcro in the nuclear envelope: LBR and LAPs

FEBS Letters

Rassadi, Roozbeh¹  Chu, Angel¹  Stochaj, Ursula¹ 

[1] Department of Physiology, 3655 Drummond Street, Montreal, Que. H3G 1Y6, Canada

关键词: Nuclear envelope;    Nuclear lamina;    Chromatin;    Lamin B receptor;    Lamina-associated protein;    EDMD;    Emery-Dreifuss muscular dystrophy;    ER;    endoplasmic reticulum;    FRAP;    fluorescence recovery after photobleaching;    GFP;    green fluorescent protein;    INM;    inner nuclear membrane;    LAP;    lamina-associated protein;    LBR;    lamin B receptor;    NE;    nuclear envelope;    NLS;    nuclear localization sequence;    NPC;    nuclear pore complex;    ONM;    outer nuclear membrane;   

DOI  :  10.1016/S0014-5793(98)01534-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The nuclear envelope is crucial for the functional organization of the nucleus. Lamin B receptor (LBR) and several lamina-associated proteins (LAPs), residing in the inner membrane, provide attachment sites for chromatin and the nuclear lamina. LAPs and LAP-related proteins are members of a growing family of proteins, whose genes are expressed in a tissue and development specific manner, opening the opportunity for a complex regulation of membrane-chromatin and membrane-lamina interactions. Post-translational modifications of LBR and LAPs are likely to modulate their binding to lamins and chromatin, interactions that need to be dynamic to accommodate nuclear growth in interphase and nuclear envelope disassembly in mitosis. Accumulation of proteins in the inner nuclear membrane is believed to depend on their retention mediated by the interaction with nuclear components such as chromatin and lamins.

【 授权许可】

Unknown