Positive feedback regulation of type I IFN genes by the IFN‐inducible transcription factor IRF‐7

FEBS Letters

Hata, Naoki¹  Taniguchi, Tadatsugu¹  Tanaka, Nobuyuki¹  Nakaya, Takeo¹  Sato, Mitsuharu¹  Asagiri, Masataka¹ 

[1] Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan

关键词: Interferon-α;    Interferon-β;    Interferon-3;    Interferon regulatory factor-7;    p48;    Transcriptional regulation;    IFN;    interferon;    IRF;    IFN regulatory factor;    IRF-E;    IRF-element;    ISRE;    IFN stimulated response element;    NDV;    Newcastle disease virus;    ISGF3;    IFN stimulated gene factor 3;    EF;    embryonic fibroblast;    EMSA;    electrophoretic mobility shift assay;   

DOI  :  10.1016/S0014-5793(98)01514-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The interferon regulatory factor (IRF) family of transcription factors regulate the interferon (IFN) system, among which IRF-3 is involved in the virus-induced IFN-β gene expression. Here we show that another member IRF-7 is critical for the IFN-α gene induction. Unlike the IRF-3 gene, the IRF-7 gene is induced by IFNs through activation of the ISGF3 transcription factor, and IRF-7 undergoes virus-induced nuclear translocation. In cells lacking p48, an essential component of IFN stimulated gene factor 3 (ISGF3), ectopic expression of IRF-7 but not IRF-3 can rescue the deficiency to induce IFN-α genes. These results indicate that IRF-7 is a key factor in the positive feedback regulation of IFN-α/β production.

【 授权许可】

Unknown