The structure of the most studied DNA fragment changes under the influence of ions: a new packing of d(CGCGAATTCGCG)

FEBS Letters

Liu, Jie¹  Malinina, Lucy¹  Huynh-Dinh, Tam²  Subirana, Juan A¹ 

[1] Departament d'Enginyeria Quı́mica, Universitat Politènica de Catalunya, Av. Diagonal 647, E-08028 Barcelona, Spain;Unité de Chimie Organique, Institut Pasteur, 28 R. du Dr. Roux, 75724 Paris, France

关键词: B-DNA structure;    Oligonucleotide;    X-ray crystallography;    Calcium ion;   

DOI  :  10.1016/S0014-5793(98)01295-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The title oligonucleotide and many related dodecamers have been extensively studied alone and as DNA-drug complexes. In practically all cases they were found to crystallize in the same space group, stabilized by interactions among the terminal guanine bases. Here we report new packing interactions (R3) in the presence of Ca²⁺. The oligonucleotides interact by placing their terminal guanines in the narrow groove of a neighbor molecule, an interaction which had never been found in dodecamers.

【 授权许可】

Unknown