Antioxidant properties of ticlopidine on human low density lipoprotein oxidation

FEBS Letters

Bruno, Cristiana¹  de Gioia, Sergio¹  Porreca, Ettore¹  Lapenna, Domenico¹  Cuccurullo, Franco¹  Ciofani, Giuliano¹  Pierdomenico, Sante D¹ 

[1] Dipartimento di Medicina e Scienze dell'Invecchiamento, Università degli Studi ‘G. d'Annunzio’, Facoltà di Medicina e Chirurgia, Chieti, Italy

关键词: Ticlopidine;    Low density lipoprotein oxidation;    Antioxidant;    Atherosclerosis;   

DOI  :  10.1016/S0014-5793(98)01166-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We found that ticlopidine, at therapeutically relevant concentrations (2.5–10 μM), but not aspirin nor salicylate, significantly counteracted copper-driven human LDL oxidation. Ticlopidine, at 5 and 10 μM, was also antioxidant on peroxyl radical-induced LDL oxidation; yet it was ineffectual on thiol and ascorbate oxidation mediated by peroxyl radicals themselves, suggesting that drug antioxidant capacity is somehow related to the lipoprotein nature of the oxidizable substrate, but not to radical scavenging. The drug could not indeed react with the stable free radical 1,1-diphenyl-2-pycrylhydrazyl, nor had apparent metal complexing-inactivating activity. Thus, ticlopidine has antioxidant effects on LDL oxidation, which, together with its anti-platelet activity, could confer peculiar antiatherogenic properties to the drug in vivo.

【 授权许可】

Unknown