Enhancement and inhibition of snake venom phosphodiesterase activity by lysophospholipids

FEBS Letters

Haimovitz, Rachel¹  Mamillapalli, Ramanaiah¹  Shinitzky, Meir¹  Ohad, Mazor² 

[1] Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel;Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel

关键词: Phosphodiesterase;    Cyclic lysophosphatidic acid;    Snake venom;    Cyclic AMP;   

DOI  :  10.1016/S0014-5793(98)01142-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Lysophospholipids are liberated during venomous action. In this study we demonstrated that lysophosphatidyl choline (LPC) of various acyl chains enhances considerably the activity of snake venom phosphodiesterase (PDE). Lysophosphatidic acid (LPA) and its cyclic form (cLPA), on the other hand, were found to inhibit this enzyme in a non-competitive (LPA) or competitive (cLPA) manner. Both of these activities may contribute to the progression and subsidence of the poisoning profile. PDE from cellular origin was not substantially affected by any of the above lysophospholipids.

【 授权许可】

Unknown