Collagen type XVI expression is modulated by basic fibroblast growth factor and transforming growth factor‐β

FEBS Letters

Chu, Mon-Li²  Tan, Elaine M.L³  Timpl, Rupert¹  Grässel, Susanne² 

[1] Dept. of Protein Chemistry, Max-Planck-Institut, Martinsried, Germany;Dept. of Dermatology and Cutaneous Biology, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA;Dept. of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA

关键词: Transforming growth factor-β;    Basic fibroblast growth factor;    Collagen XVI;    Arterial smooth muscle cell;    Dermal fibroblast;    TGF-β;    transforming growth factor-β;    bFGF;    basic fibroblast growth factor;    ECM;    extracellular matrix;   

DOI  :  10.1016/S0014-5793(98)01122-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We investigated the effects of bFGF and TGF-β on the expression of type XVI collagen, a member of the fibril associated collagen family, in human dermal fibroblasts and arterial smooth muscle cells. We found that bFGF decreased the α1(XVI) collagen mRNA to 18–24% of the controls, while TGF-β increased the mRNA to 150–360%. Immunoprecipitation of metabolically labeled cells revealed corresponding, but less pronounced, changes at the protein levels. The results suggested that type XVI collagen expression is regulated by bFGF and TGF-β in a manner similar to their regulation of the major type I fibrillar collagen produced by these cells.

【 授权许可】

Unknown