Intestinal lactase‐phlorizin hydrolase (LPH): the two catalytic sites; the role of the pancreas in pro‐LPH maturation

FEBS Letters

Poirée, Jean-Claude¹  Giudicelli, Jean¹  Cursio, Raffaele²  Gloor, Sergio M³  Stutz, Alfred³  Mesonero, José E³  Semenza, Giorgio⁴  Zecca, Laura³ 

[1]Laboratoire de Biochimie, Faculté de Médecine, Université de Nice, F-06107 Nice Cedex, France

[2]Laboratoire de Chirurgie Expérimental, Faculté de Médecine, Université de Nice, F-06107 Nice Cedex, France

[3]Department of Biochemistry, Swiss Federal Institute of Technology, ETH Zentrum, CH-8092 Zurich, Switzerland

[4]Dipartimento di Chimica e Biochimica Medica, Università di Milano, Milan, Italy

关键词: Lactase;    Active site;    Proteolytic processing;    Pancreas;   

DOI  :  10.1016/S0014-5793(98)01076-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The proteolytic processing of pro-lactase-phlorizin hydrolase by (rat) enterocytes stops two amino acid residues short of the N-terminus of ‘mature’ final, brush border lactase-phlorizin hydrolase. Only these two amino acid residues are removed by luminal pancreatic protease(s), probably trypsin.

【 授权许可】

Unknown