Lysophosphatidylcholine upregulates CD40 ligand expression in newly activated human CD4+ T cells

FEBS Letters

Usui, Takashi¹  Kita, Toru¹  Wakatsuki, Yoshio¹  Kume, Noriaki¹  Nishi, Eiichiro¹  Sakata-Kaneko, Shizuka¹  Itoh, Toshiyuki¹  Matsunaga, Yoichi¹ 

[1] Department of Clinical Bio-regulatory Science, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogo-in, Sakyo-ku, Kyoto 606-8507, Japan

关键词: Lysophosphatidylcholine;    CD28-CD80 costimulation;    CD4 T cell;    CD40 ligand;    Atherosclerosis;    CD40L;    CD40 ligand;    Th1/Th2;    T helper type 1/T helper type 2;    TCR;    T cell receptor;    FITC;    fluorescein isothiocyanate;    PE;    phycoerythrin;    LFA-1;    lymphocyte function-associated antigen 1;    JNK;    c-jun N-terminal kinase;    PBMC;    peripheral blood mononuclear cell;   

DOI  :  10.1016/S0014-5793(98)00898-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Lysophosphatidylcholine (lyso-PC) accumulates in tissues undergoing inflammation and atherosclerosis, where an infiltration of T cells is also seen. We found that lyso-PC increased IFN-γ production and CD40L expression in CD4+ T cells stimulated with anti-CD3 Ab and recombinant CD80 molecules, whereas lyso-PC did not affect IL-2 and IL-4 production. These results suggest that lyso-PC, in combination with other stimuli, may regulate CD4+ T cell functions to propagate local inflammatory reactions and also imply a novel role played by a modified lipid in the selection of Th1/Th2 immune response as well as in the T cell mediated pathogenesis in atherosclerosis.

【 授权许可】

Unknown