Voltage gating is a fundamental feature of porin and toxin β‐barrel membrane channels

FEBS Letters

Bainbridge, Graeme¹  Lakey, Jeremy H¹  Gokce, Isa¹ 

[1] Department of Biochemistry and Genetics, The Medical School, University of Newcastle Upon Tyne, Newcastle Upon Tyne NE2 4HH, UK

关键词: Beta-barrel pore;    Voltage gating;   

DOI  :  10.1016/S0014-5793(98)00761-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Beta-barrel pores are found in outer membrane porins of Gram-negative bacteria, bacterial toxins and mitochondrial channels. Apart from the β-barrel the three groups show no close sequence or structural homology but these pores exhibit symmetrical voltage gating when reconstituted into planar lipid bilayers. The structures of several of these are known and many site-directed mutants have been examined. As a result it seems evident that the gating is a common characteristic of these unrelated large pores and is not generated by specialised structures in the pore lumen.

【 授权许可】

Unknown