Increased caveolin‐3 levels in mdx mouse muscles

FEBS Letters

Fang, Jin¹  P. Vaghy, Laszlo¹  Vaghy, Pal L.¹  Wu, Wenrong¹ 

[1] Department of Medical Biochemistry, College of Medicine, The Ohio State University, 1645 Neil Avenue, Columbus, OH 43210, USA

关键词: Muscular dystrophy;    Duchenne;    Mdx mouse;    Caveolin;    Nitric oxide;   

DOI  :  10.1016/S0014-5793(98)00738-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The density of skeletal muscle caveolae is increased in Duchenne muscular dystrophy and its genetic homologue, the mdx mouse. This structural change is significant as it may indicate muscle regeneration. We identified in mdx mouse tibialis anterior muscles significantly increased levels of caveolin-3, the chief protein in muscle caveolae, and reduced levels of neuronal nitric oxide synthase, an enzyme regulated by caveolin-3. Similar changes occurred in the corresponding mRNA levels. These data suggest that induction of caveolin-3 occurs and this may at least partly be responsible for increased number of caveolae, altered nNOS-caveolin cycle, and regeneration of dystrophic muscles.

【 授权许可】

Unknown