Quercetin metabolites inhibit copper ion‐induced lipid peroxidation in rat plasma

FEBS Letters

Moon, Jae-Hak²  da Silva, Edson L¹  Yamamoto, Norio⁴  Piskula, Mariusz K³  Terao, Junji² 

[1] Universidade Federal de Santa Catarina, Centro de Ciencias da Saude, Florianopolis-Santa Catarina 88040-900, Brazil;Deparment of Nutrition, School of Medicine, The University of Tokushima, Kuramoto-cho 3, Tokushima 770, Japan;Institute of Animal Reproduction and Food Research. Tuwima 10, 10-718 Olsztyn, Poland;Takeda Food Products, Ltd., Itami, Hyogo 664, Japan

关键词: Flavonoid;    Quercetin;    Conjugated metabolite;    Antioxidant;    Lipid peroxidation;   

DOI  :  10.1016/S0014-5793(98)00709-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The oxidative susceptibility of plasma obtained from rats after intragastric administration of quercetin was studied to know whether or not quercetin acts as an in vivo antioxidant after metabolic conversion. Quercetin was raised in the rat blood plasma essentially as glucuronide and/or sulfate conjugates. The plasma obtained from rats after quercetin administration was more resistant against copper sulfate-induced lipid peroxidation than the control plasma on the basis of the accumulation of cholesteryl ester hydroperoxides and the consumption of α-tocopherol. The results strongly suggest that some conjugated metabolites of quercetin act as effective antioxidants when plasma is subject to metal ion-induced lipid peroxidation.

【 授权许可】

Unknown