The thermosome: archetype of group II chaperonins

FEBS Letters

Baumeister, Wolfgang¹  Klumpp, Martin¹ 

[1] Max-Planck-Institut für Biochemie, D-82152 Martinsried, Germany

关键词: Protein folding;    Chaperone;    TRiC/CCT;    Archaeon;   

DOI  :  10.1016/S0014-5793(98)00541-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The thermosome, the chaperonin of the archaea, and its homologue from the cytosol of eukaryotes, known as TRiC or CCT, form a distinct subfamily of the chaperonins that does not depend on a co-chaperonin for protein folding activity. Recent structural data obtained by cryo- electron microscopy and X-ray crystallography provide the first insights into a novel mechanism remarkably different from that of the bacterial GroEL-GroES system.

【 授权许可】

Unknown