FEBS Letters | |
A non‐peptide compound which can mimic the effect of thrombopoietin via c‐Mpl | |
Kimura, Tatsuya1  Watanabe, Yoshinari1  Ikeda, Yoshitaka1  Kato, Hideo1  Kaburaki, Hiroshi1  Tsujino, Tomomi1  | |
[1] Research and Development Division, Hokuriku Seiyaku Co., Ltd., Inokuchi, Katsuyama, Fukui 911-8555, Japan | |
关键词: Thrombopoietin; c-Mpl; Benzodiazepinone; Signal transducer and activator of transcription; | |
DOI : 10.1016/S0014-5793(98)00536-5 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Thrombopoietin (TPO) is a cytokine which plays a central role in megakaryopoiesis and platelet production by binding to its cell surface receptor, termed c-Mpl. In the present study, two benzodiazepinones that compete with the binding of TPO to the extracellular region of c-Mpl were identified, and one of them stimulated the proliferation of a human TPO-dependent megakaryocytic cell line, UT-7/TPO. It stimulated the activation of signal transducer and activator of transcription 5 in UT-7/TPO cells. These results suggest that a non-peptide compound can mimic the effect of TPO via c-Mpl.
【 授权许可】
Unknown
【 预 览 】
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