A non‐peptide compound which can mimic the effect of thrombopoietin via c‐Mpl

FEBS Letters

Kimura, Tatsuya¹  Watanabe, Yoshinari¹  Ikeda, Yoshitaka¹  Kato, Hideo¹  Kaburaki, Hiroshi¹  Tsujino, Tomomi¹ 

[1] Research and Development Division, Hokuriku Seiyaku Co., Ltd., Inokuchi, Katsuyama, Fukui 911-8555, Japan

关键词: Thrombopoietin;    c-Mpl;    Benzodiazepinone;    Signal transducer and activator of transcription;   

DOI  :  10.1016/S0014-5793(98)00536-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Thrombopoietin (TPO) is a cytokine which plays a central role in megakaryopoiesis and platelet production by binding to its cell surface receptor, termed c-Mpl. In the present study, two benzodiazepinones that compete with the binding of TPO to the extracellular region of c-Mpl were identified, and one of them stimulated the proliferation of a human TPO-dependent megakaryocytic cell line, UT-7/TPO. It stimulated the activation of signal transducer and activator of transcription 5 in UT-7/TPO cells. These results suggest that a non-peptide compound can mimic the effect of TPO via c-Mpl.

【 授权许可】

Unknown