The murine gap junction gene connexin36 is highly expressed in mouse retina and regulated during brain development

FEBS Letters

Degen, Joachim¹  Willecke, Klaus¹  Teubner, Barbara¹  Söhl, Goran¹ 

[1] Institut für Genetik, Abteilung Molekulargenetik, Universität Bonn, 53117 Bonn, Germany

关键词: Rat connexin36 cDNA;    Mouse connexin36 gene;    Connexin δ subgroup;    Retinal connexin;    RT-PCR;    reverse transcription polymerase chain reaction;    Cx;    connexin;    GAPDH;    glyceraldehydephosphate dehydrogenase;    UTR;    untranslated region;   

DOI  :  10.1016/S0014-5793(98)00479-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A new gap junction gene isolated from rat brain cDNA, mouse retina cDNA and mouse genomic DNA is called connexin36, since it codes for a connexin protein of 321 amino acids corresponding to the theoretical molecular mass of 36 045 kDa (rat) and 36 084 kDa (mouse). Only one amino acid residue differs between rat and mouse connexin36. In the single murine connexin36 gene, an 1.14-kb intron interrupts the coding region, similar as in the homologous skate connexin35 gene. Because of this unique feature, mouse connexin36 differs from the other 13 murine connexin genes and is suggested to form a new δ subclass of connexins. Connexin36 mRNA (2.9 kb) is highly expressed in adult retina and less abundant in brain where it gradually increased during fetal development until day 7 post partum, and decreased thereafter.

【 授权许可】

Unknown