Expression of Hex mRNA in early murine postimplantation embryo development

FEBS Letters

Fujimori, Kazuhiro E.¹  Noguchi, Tamio²  Nojyo, Yoshiaki¹  Keng, Vincent W.²  Myint, Zaw²  Tamamaki, Nobuaki¹ 

[1]Department of Anatomy, Fukui Medical University, Fukui 910-1193, Japan

[2]Department of Biochemistry, Fukui Medical University, Fukui 910-1193, Japan

关键词: Hex;    Liver;    Thyroid;    Lung;    In situ hybridization;    Murine embryo;    E;    embryonic age;    PB;    phosphate buffer;    HNF;    hepatocyte nuclear factor;    TTF1;    thyroid transcription factor 1;   

DOI  :  10.1016/S0014-5793(98)00342-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The onset of Hex expression and its role in early murine development was analyzed using in situ hybridization. Hex mRNA was first detected in the chorion of the ectoplacental cavity and weakly at the visceral endoderm of the future yolk sac at embryonic age (E) 7.5. Expression in embryonic tissues was detected exclusively in the hepatic anlage and thyroid primordium at E 9.5. At E 12.5 and E 15.5, Hex expression persisted in the fetal liver and thyroid, and was also detected in the fetal lung. These results suggest that Hex has its role in differentiation and/or organogenesis of several embryonic tissues.

【 授权许可】

Unknown