Do transmembrane protein superfolds exist?

FEBS Letters

Jones, David T¹ 

[1] Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK

关键词: Transmembrane protein;    Protein structure prediction;    Protein superfold;   

DOI  :  10.1016/S0014-5793(98)00095-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A reliable and widely used transmembrane protein structure prediction algorithm was applied to five representative genomic sequence data sets in order to re-examine the hypothesis that in contrast to globular proteins there are no favored transmembrane protein fold families. When the number of predicted membrane spanning segments and the topology of these segments is taken into account then definite biases are observed which suggest that certain transmembrane topologies are significantly more common than others.

【 授权许可】

Unknown