African origin of GB virus C/hepatitis G virus

FEBS Letters

Zekeng, Leopold²  Mboudjeka, Innocent²  Kondo, Yutaka⁵  Bikandou, Blaise³  Kaptue, Lazare²  Kato, Takanobu⁵  Hayami, Masanori⁴  Takehisa, Jun⁴  M'Pele, Pierre³  Ohba, Ken-ichi⁵  Mizokami, Masashi⁵  Suzuki, Yoshiyuki¹  Tanaka, Yasuhito⁵  Gojobori, Takashi¹  Orito, Etsuro⁵ 

[1] Center for Information Biology, National Institute of Genetics, Mishima, Japan;Laboratoire d'Hématologie et d'Immunologie, Centre Hospitalier Universitaire, Yaounde, Cameroon;Cité Louis Pasteur-Laboratoire National de Santé Publique, Brazzaville, Congo;Institute for Virus Research, Kyoto University, Kyoto, Japan;Second Department of Medicine, Nagoya City University Medical School, Kawasumi, Mizuho, Nagoya 467, Japan

关键词: GB virus C;    Hepatitis G virus;    Africa;    Pygmy;    Indel;    NS5A;    Phylogenetic analysis;   

DOI  :  10.1016/S0014-5793(98)00083-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Ninety-four GB virus C/hepatitis G virus (GBV-C/HGV) RNA-positive serum samples were obtained from all over the world. We found that all 15 GBV-C/HGV isolates from the Pygmies and the Bantu in the Central African region had a 12-amino acid indel (i.e. insertion or deletion) in the non-structural protein (NS) 5A region. Phylogenetic analyses of the NS5A region, using GBV-A as an outgroup, showed that these 15 isolates had diverged from the common ancestor much earlier than the remaining isolates, indicating an African origin of GBV-C/HGV.

【 授权许可】

Unknown