FEBS Letters | |
Vascular types I and II transforming growth factor‐beta receptor expression: differential dependency on tyrosine kinases during induction by TGF‐β | |
Jennings, Garry1  Agrotis, Alex1  Ward, Michael R1  Bobik, Alex1  | |
[1] Cell Biology Laboratory, Baker Medical Research Institute and Alfred Hospital, Prahran, Vic., Australia | |
关键词: Transforming growth factor-β; Tyrosine kinase inhibition; Transforming growth factor-β receptor gene expression; Vascular smooth muscle; | |
DOI : 10.1016/S0014-5793(98)00011-8 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Recent evidence indicates that the type II transforming growth factor-β (TGF-β) receptor (TβRII) is a serine-threonine-tyrosine kinase. However, the significance of its tyrosine kinase is unclear. We investigated in vascular smooth muscle cells the effects of tyrosine kinase inhibition on the expression of TGF-β receptor types I (ALK-5) and II (TβRII) mRNA, induced by TGF-β 1. TGF-β 1 elevated ALK-5 mRNA levels 5-fold; essentially similar TGF-β 1-dependent elevations were observed with growth factors, PDGF-BB and FGF-2. The tyrosine kinase inhibitor genistein abolished these TGF-β 1 and growth factor responses. TGF-β 1 also elevated TβRII mRNA levels which were not inhibited by genistein. We conclude that tyrosine kinases participate in defining how cells respond to TGF-β.
【 授权许可】
Unknown
【 预 览 】
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RO201912020305504ZK.pdf | 140KB | download |